Random walk and quantitative stratigraphical sequences

A sequence of digitized observations on short-normal resistivity determinations seems to show trend from higher to lower values. An appropriate statistical model proves it to have less range than expected on the distribution of its successive increments. On a two-tailed statistical procedure for testing deviations from a random walk, the series tends towards ‘stasis’ rather than trend. The random walk model is shown to be plausible for the problem considered.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73590/1/j.1365-3121.1992.tb00465.x.pd

Landmark detection in 2D bioimages for geometric morphometrics: a multi-resolution tree-based approach

The detection of anatomical landmarks in bioimages is a necessary but tedious step for geometric morphometrics studies in many research domains. We propose variants of a multi-resolution tree-based approach to speed-up the detection of landmarks in bioimages. We extensively evaluate our method variants on three different datasets (cephalometric, zebrafish, and drosophila images). We identify the key method parameters (notably the multi-resolution) and report results with respect to human ground truths and existing methods. Our method achieves recognition performances competitive with current existing approaches while being generic and fast. The algorithms are integrated in the open-source Cytomine software and we provide parameter configuration guidelines so that they can be easily exploited by end-users. Finally, datasets are readily available through a Cytomine server to foster future research

Probabilistic models of information retrieval based on measuring the divergence from randomness

We introduce and create a framework for deriving probabilistic models of Information Retrieval. The models are nonparametric models of IR obtained in the language model approach. We derive term-weighting models by measuring the divergence of the actual term distribution from that obtained under a random process. Among the random processes we study the binomial distribution and Bose--Einstein statistics. We define two types of term frequency normalization for tuning term weights in the document--query matching process. The first normalization assumes that documents have the same length and measures the information gain with the observed term once it has been accepted as a good descriptor of the observed document. The second normalization is related to the document length and to other statistics. These two normalization methods are applied to the basic models in succession to obtain weighting formulae. Results show that our framework produces different nonparametric models forming baseline alternatives to the standard tf-idf model

New quantitative approaches reveal the spatial preference of nuclear compartments in mammalian fibroblasts

The nuclei of higher eukaryotic cells display compartmentalization and certain nuclear compartments have been shown to follow a degree of spatial organization. To date, the study of nuclear organization has often involved simple quantitative procedures that struggle with both the irregularity of the nuclear boundary and the problem of handling replicate images. Such studies typically focus on inter-object distance, rather than spatial location within the nucleus. The concern of this paper is the spatial preference of nuclear compartments, for which we have developed statistical tools to quantitatively study and explore nuclear organization. These tools combine replicate images to generate ‘aggregate maps' which represent the spatial preferences of nuclear compartments. We present two examples of different compartments in mammalian fibroblasts (WI-38 and MRC-5) that demonstrate new knowledge of spatial preference within the cell nucleus. Specifically, the spatial preference of RNA polymerase II is preserved across normal and immortalized cells, whereas PML nuclear bodies exhibit a change in spatial preference from avoiding the centre in normal cells to exhibiting a preference for the centre in immortalized cells. In addition, we show that SC35 splicing speckles are excluded from the nuclear boundary and localize throughout the nucleoplasm and in the interchromatin space in non-transformed WI-38 cells. This new methodology is thus able to reveal the effect of large-scale perturbation on spatial architecture and preferences that would not be obvious from single cell imaging

Comparison of geometric morphometric outline methods in the discrimination of age-related differences in feather shape

BACKGROUND: Geometric morphometric methods of capturing information about curves or outlines of organismal structures may be used in conjunction with canonical variates analysis (CVA) to assign specimens to groups or populations based on their shapes. This methodological paper examines approaches to optimizing the classification of specimens based on their outlines. This study examines the performance of four approaches to the mathematical representation of outlines and two different approaches to curve measurement as applied to a collection of feather outlines. A new approach to the dimension reduction necessary to carry out a CVA on this type of outline data with modest sample sizes is also presented, and its performance is compared to two other approaches to dimension reduction. RESULTS: Two semi-landmark-based methods, bending energy alignment and perpendicular projection, are shown to produce roughly equal rates of classification, as do elliptical Fourier methods and the extended eigenshape method of outline measurement. Rates of classification were not highly dependent on the number of points used to represent a curve or the manner in which those points were acquired. The new approach to dimensionality reduction, which utilizes a variable number of principal component (PC) axes, produced higher cross-validation assignment rates than either the standard approach of using a fixed number of PC axes or a partial least squares method. CONCLUSION: Classification of specimens based on feather shape was not highly dependent of the details of the method used to capture shape information. The choice of dimensionality reduction approach was more of a factor, and the cross validation rate of assignment may be optimized using the variable number of PC axes method presented herein

A Compromise between Neutrino Masses and Collider Signatures in the Type-II Seesaw Model

A natural extension of the standard $SU(2)_{\rm L} \times U(1)_{\rm Y}$ gauge model to accommodate massive neutrinos is to introduce one Higgs triplet and three right-handed Majorana neutrinos, leading to a $6\times 6$ neutrino mass matrix which contains three $3\times 3$ sub-matrices $M_{\rm L}$, $M_{\rm D}$ and $M_{\rm R}$. We show that three light Majorana neutrinos (i.e., the mass eigenstates of $\nu_e$, $\nu_\mu$ and $\nu_\tau$) are exactly massless in this model, if and only if $M_{\rm L} = M_{\rm D} M_{\rm R}^{-1} M_{\rm D}^T$ exactly holds. This no-go theorem implies that small but non-vanishing neutrino masses may result from a significant but incomplete cancellation between $M_{\rm L}$ and $M_{\rm D} M_{\rm R}^{-1} M_{\rm D}^T$ terms in the Type-II seesaw formula, provided three right-handed Majorana neutrinos are of ${\cal O}(1)$ TeV and experimentally detectable at the LHC. We propose three simple Type-II seesaw scenarios with the $A_4 \times U(1)_{\rm X}$ flavor symmetry to interpret the observed neutrino mass spectrum and neutrino mixing pattern. Such a TeV-scale neutrino model can be tested in two complementary ways: (1) searching for possible collider signatures of lepton number violation induced by the right-handed Majorana neutrinos and doubly-charged Higgs particles; and (2) searching for possible consequences of unitarity violation of the $3\times 3$ neutrino mixing matrix in the future long-baseline neutrino oscillation experiments.Comment: RevTeX 19 pages, no figure

Skeletal and dental changes following functional regulator therapy on class II patients

Craniofacial growth in 100 patients treated with the functional regulator of Frankel for about 24 months was compared with craniofacial growth seen in a matched group of untreated persons with Class II malocclusion. Both conventional and geometric cephalometric analyses were used to evaluate the skeletal and dental adaptations. This study shows several clear effects of treatment in either of two age ranges considered. The principal skeletal effect was advancement of the mandible along the direction of the facial axis. This advancement resulted in increases in mandibular length and in vertical facial dimensions. There was little effect of treatment upon maxillary skeletal structures with the exception of point A, which moved slightly posteriorly. Dentoalveolar adaptations due to treatment included a decrease in the normal forward movement of the upper molar and an increase in the normal vertical movement of the lower molar. There was a 2-mm posterior movement of the tip of the upper incisor but minimal anterior tipping of the lower incisor.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25601/1/0000148.pd

Zika virus impairs the development of blood vessels in a mouse model of congenital infection

Zika virus (ZIKV) is associated with brain development abnormalities such as primary microcephaly, a severe reduction in brain growth. Here we demonstrated in vivo the impact of congenital ZIKV infection in blood vessel development, a crucial step in organogenesis. ZIKV was injected intravenously in the pregnant type 2 interferon (IFN)-deficient mouse at embryonic day (E) 12.5. The embryos were collected at E15.5 and postnatal day (P)2. Immunohistochemistry for cortical progenitors and neuronal markers at E15.5 showed the reduction of both populations as a result of ZIKV infection. Using confocal 3D imaging, we found that ZIKV infected brain sections displayed a reduction in the vasculature density and vessel branching compared to mocks at E15.5; altogether, cortical vessels presented a comparatively immature pattern in the infected tissue. These impaired vascular patterns were also apparent in the placenta and retina. Moreover, proteomic analysis has shown that angiogenesis proteins are deregulated in the infected brains compared to controls. At P2, the cortical size and brain weight were reduced in comparison to mock-infected animals. In sum, our results indicate that ZIKV impairs angiogenesis in addition to neurogenesis during development. The vasculature defects represent a limitation for general brain growth but also could regulate neurogenesis directly

Do Not Mask What You Do Not Need to Mask: a Parser-Free Virtual Try-On

The 2D virtual try-on task has recently attracted a great interest from the research community, for its direct potential applications in online shopping as well as for its inherent and non-addressed scientific challenges. This task requires fitting an in-shop cloth image on the image of a person, which is highly challenging because it involves cloth warping, image compositing, and synthesizing. Casting virtual try-on into a supervised task faces a difficulty: available datasets are composed of pairs of pictures (cloth, person wearing the cloth). Thus, we have no access to ground-truth when the cloth on the person changes. State-of-the-art models solve this by masking the cloth information on the person with both a human parser and a pose estimator. Then, image synthesis modules are trained to reconstruct the person image from the masked person image and the cloth image. This procedure has several caveats: firstly, human parsers are prone to errors; secondly, it is a costly pre-processing step, which also has to be applied at inference time; finally, it makes the task harder than it is since the mask covers information that should be kept such as hands or accessories. In this paper, we propose a novel student-teacher paradigm where the teacher is trained in the standard way (reconstruction) before guiding the student to focus on the initial task (changing the cloth). The student additionally learns from an adversarial loss, which pushes it to follow the distribution of the real images. Consequently, the student exploits information that is masked to the teacher. A student trained without the adversarial loss would not use this information. Also, getting rid of both human parser and pose estimator at inference time allows obtaining a real-time virtual try-on.Comment: Accepted at ECCV 2020. arXiv admin note: text overlap with arXiv:1906.0134